The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity
NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers, including aggressive pancreatic tumors.Recent studies have indicated a role for NDRG1 in the inhibition of multiple tyrosine kinases, including EGFR, c-Met, HER2 and HER3, etc.The mechanism of activity of NDRG1 remains unclear, but to impart some of its functions,